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Traveling around the world, you may catch a disease. A disease affects an organ and begins to block gradually active and passive skills dependent of this organ, and casts additional effects on the character.
If you can’t find a cure, the disease will progress, affecting nearby organs, and can destroy the organism altogether.
However, strange though it may sound, players will almost always have a chance to cure a disease and even make use of its effects. It is up to you whether to treat a disease without losing any skills and organs or to experiment with it.